• Publications

Publications from the Cecilia Flores Lab

See our publications in Pubmed

Reynolds LM, Pokinko M, Torres-Berrio A, Cuesta S, Lambert LC, Del Cid Pellitero E, Wodzinski M, Manitt C, Krimpenfort P, Kolb B, Flores C (2017). DCC receptors drive prefrontal cortex maturation by determining dopamine axon targeting in adolescence. Biological Psychiatry, In Press

Torres-Berrío A, Lopez JP, Bagot RC, Nouel D, Dal-Bo G, Cuesta S, Zhu L, Manitt C, Eng C, Cooper H, Storch F, Turecki G, Nestler EJ, Flores C (2017). DCC confers susceptibility to depression-like behaviors in humans and mice and is regulated by miR-218. Biological Psychiatry 81(4):306-315

Verwey M, Grant A, Meti N, Adye-White L, Torres-Berrío A, Rioux V, Lévesque M, Charron F, Flores C. (2016) Mesocortical Dopamine Phenotypes in Mice Lacking the Sonic Hedgehog Receptor Cdon. eNeuro Jul 13;3(3)

Reynolds LM, Gifuni AJ, McCrea ET, Shizgal P, Flores C. (2016) dcc haploinsufficiency results in blunted sensitivity to cocaine enhancement of reward seeking. Behavioural Brain Research 298(A): 27–31
Invited Submission to Special Issue: Developmental Regulation of Memory in Anxiety and Addiction

Pokinko M, Moquin L, Torres-Berrio A, Gratton A, Flores C. (2015) Resilience to Amphetamine in Mouse Models of Netrin-1 Haploinsufficiency: Role of Mesocortical Dopamine Psychopharmacology 20:3719-29

Reynolds LM, Makowski CS, Yogendran SV, Kiessling S, Cermakian N, Flores C. (2015) Amphetamine in adolescence disrupts the development of medial prefrontal cortex dopamine connectivity in a dcc-dependent manner. Neuropsychopharmacology 40: 1101-1112

Grant A, Manitt C, Flores C. (2014) Haloperidol treatment downregulates DCC expression in the ventral tegmental area. Neuroscience Letters 575: 58-62

Liang D-Y, Zheng M, Sun Y, Sahbaie P, Low S.A, Peltz G, Scherrer G, Flores C, Clark D. (2014) The Netrin-1 Receptor DCC is a Regulator of Maladaptive Responses to Chronic Morphine Administration. BMC Genomics 15:345.

Yetnikoff L, Pokinko M, Arvanitogiannis, Flores C. (2014) Adolescence: A Time of transition for the phenotype of dcc heterozygous mice. Psychopharmacology. 231(8): 1705-14.

Daubaras M, Dal-Bo G, Flores C. (2013) Target-dependent expression of the netrin-1 receptor, UNC5C, in projection neurons of the ventral tegmental area. Neuroscience 260C:36-46.

Manitt C*, Eng C*, Pokinko M, Ryan R, Torres-Berrío A, Lopez JP, Yogendran S, Daubaras M, Grant A, Schmidt E, Tronche F, Krimpenfort P, Cooper H, Pasterkamp J, Kolb B, Turecki G, Wong TP, Nestler E, Giros B, Flores C. (2013) dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients. Translational Psychiatry 3:e338.

*contributed equally to this work

This article was featured on the Canadian National News Network (CTV). It was also covered by Douglas Hospital News, ABC2News, the Boston Globe, Global News, Healthline News, Wired, Genetic Engineering & Biotechnology News, Medical Daily, Top News Arab Emirates, and Mental Health Association Australia.

Kim J, Lavan D, Chen N, Flores C, Cooper H, Lawrence A. (2013) Netrin-1 receptor-deficient mice show age-specific impairment in drug-induced locomotor hyperactivity but still self-administer methamphetamine. Psychopharmacology 230:607-616

Auger M, Schmidt E, Manitt C, Dal-Bo G, Pasterkamp J, Flores C. (2013) unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficient model. European Journal of Neuroscience 38:2853-2863

Aguilar-Valles A, Jung S, Poole S, Flores, C, Luheshi G. (2012) Leptin and interleukin-6 alter the development of mesolimbic dopamine neurons in a model of prenatal inflammation in rat. Psychoneuroendocrinology. 37(7): 956-969.

Grant A, Fathalli F, Rouleau G, Joober R, Flores C. (2012) Association between schizophrenia and genetic variations in DCC: a case-control study. Schizophrenia Research. 137: 26-31.

Argento J, Arvanitogiannis A, Flores C. (2012) Juvenile Exposure to Methylphenidate Reduces Cocaine Reward and Alters Netrin-1 Receptor Expression in Adulthood. Behavioural Brain Research. 229(1): 202-207.

Flores C. (2011) Role of netrin-1 in the organization of the mesocorticolimbic dopamine system. Journal of Psychiatry and Neuroscience. 36(5): 296-310.

Yetnikoff L, Almey MA, Arvanitogiannis A, Flores C. (2011) Abolition of the behavioral phenotype of adult netrin-1 receptor deficient mice by exposure to amphetamine during the juvenile period. Psychopharmacology 217: 505-514.

Manitt C, Mimee A, Eng C, Pokinko M, Stroh T, Cooper HM, Kolb B, and Flores C. (2011) The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry. Journal of Neuroscience 31(23): 8381-8394. *see This Week in The Journal section for commentary

Manitt C*, Labelle-Dumais C*, Eng C, Grant A, Mimee A, Stroh T, Flores C. (2010) Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents. PLoS One 5(7): e11463 *contributed equally to this work

Aguilar-Valles A, Flores, C, Luheshi G. (2010) Prenatal inflammation-induced hypoferremia alters dopamine function in the offspring. PLoS One 5(6): e10967

Yetnikoff L, Eng C, Benning S, Flores C. (2010) Netrin1 receptor in the ventral tegmental area is required for sensitization to amphetamine. European Journal of Neuroscience 31: 1292-1302

Grant A, Speed Z, Labelle-Dumais C, Flores C. (2009) Post-pubertal emergence of a dopaminergic phenotype in netrin-1 receptor deficient mice. European Journal of Neuroscience 30: 1318-1328

Hercher C, Parent M, Flores C, Canetti L, Mechawar N, Turecki G. (2009) An alcohol-related increase of glia cell density in the anterior cingulated cortex of suicides. Journal of Psychiatry and Neuroscience 34: 281-288

Flores C, Bhardwaj S K, Labelle-Dumais C, Srivastava L. (2009) Altered netrin-1 receptor expression in dopamine terminal regions following neonatal ventral hippocampal lesions in the rat. Synapse 63: 54-60

Grant A, Hoops D, Labelle-Dumais C, Prevost M, Rajabi H, Kolb B, Stewart J, Arvanitogiannis A Flores C. (2007) Netrin-1 receptor-deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine European Journal of Neuroscience 26:3215-3228

Yetnikoff L, Labelle-Dumais C, Flores C. (2007) Regulation of netrin-1 receptors by amphetamine in the adult brain. Neuroscience 150:764-773

Flores C, Wen X, Labelle-Dumais C, Kolb B. (2007) Chronic phencyclidine treatment increases dendritic spine density in prefrontal cortex and nucleus accumbens neurons. Synapse 61:978-984

Flores C, Manitt C, Rodaros D, Thompson KM, Rajabi H, Luk K, Tritsch N., Sadikot A, Stewart J, Kennedy TE (2005) Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine. Molecular Psychiatry 10: 606-612

Flores C and Coyle JT (2003) Regulation of glutamate carboxypeptidase II function in corticolimbic regions of rat brain by phencyclidine, haloperidol, and clozapine. Neuropsychopharmacology, 28: 1227-1243

Flores C, Stewart J, Salmaso N, Zhang Y, Boksa P. (2002) Astrocytic basic fibroblast growth factor expression in dopaminergic regions after perinatal anoxia. Biological Psychiatry, 52: 362-370

Flores C and Stewart J. (2000) Basic fibroblast growth factor as a mediator of the effects of glutamate in the development of long-lasting sensitization to stimulant drugs: studies in the rat. Psychopharmacology, 151: 152-165

Flores C and Stewart J. (2000) Changes in astrocytic basic fibroblast growth factor expression during and after prolonged exposure to escalating doses of amphetamine. Neuroscience, 98: 287-293>

Flores C, Samaha, A-N, & Stewart J. (2000) Requirement of endogenous basic fibroblast growth factor for sensitization to amphetamine. Journal of Neuroscience, 20: RC7 (1-5)

Flores C., Salmaso, N., Cain, S., Rodaros, D. & Stewart J. (1999) Ovariectomy of adult rats leads to increased expression of astrocytic basic fibroblast growth factor in the ventral tegmental area and in dopaminergic projection regions of the entorhinal and prefrontal cortex. Journal of Neuroscience, 19: 8665-8673

Flores C., Rodaros D., & Stewart J. (1998) Long-lasting induction of astrocytic basic fibroblast growth factor by repeated injections of amphetamine: blockade by concurrent treatment with a glutamate antagonist. Journal of Neuroscience, 18: 9547-9555